scientific founders/ key consultants

Scientific founders
Rick Malley, MD

Rick Malley is Affinivax’s scientific founder and the Kenneth McIntosh Chair in Pediatric Infectious Diseases at Boston Children’s Hospital. He is also the Director of the Travel and Geographic Medicine Clinic at Boston Children’s Hospital. He runs an NIH-funded laboratory where his group focuses on various aspects of bacterial pathogenesis, natural- and vaccine-induced immunity and the development of novel vaccine technologies, such as the Multiple Antigen Presenting System (MAPS). As an experienced physician with more than 20 years of experience treating infectious diseases, Dr. Malley has led an international effort in the development of novel vaccines in collaboration with colleagues and global nonprofit health organizations such as PATH and the Bill and Melinda Gates Foundation.

Fan Zhang, PhD

Fan Zhang is an Assistant Professor in Pediatrics at Harvard Medical School and joins Affinivax as a Founding Scientist. She obtained a B.S. and Ph.D. from Tsinghua University in Beijing, and completed her postdoctoral fellowship in the laboratory of Dr. Yigong Shi at Princeton University. She joined Dr. Malley’s laboratory as a post-doctoral fellow in 2010, where she has focused her work on the development of MAPS. She is a co-inventor of the MAPS technology.

Yingjie Lu, PhD

Yingjie Lu is an Assistant Professor in Pediatrics at Harvard Medical School. A graduate of Tsinghua University in Beijing, he joined Dr. Rock’s group at St. Jude’s Research Hospital for his first post-doctoral fellowship, where he worked on developing new antibiotic targets. He then joined Dr. Malley’s group as a postdoctoral fellow, rising to the level of Assistant Professor in 2012 and has been the recipient of NIH funding. He is the author of over 25 peer-reviewed publications in the field of bacterial genetics and vaccines and a co-inventor of the MAPS technology.

Key consultants and scientific advisors
Velupillai (Puvy) Puvanesarajah, PhD — Process and Analytical Development

Velupillai (Puvy) PuvanesarajahDr. Puvanesarajah brings over 25 years of experience in vaccine research, development and commercialization to Affinivax. Most recently, Dr. Puvanesarajah was a Senior Director at Sanofi Pasteur where he led all analytical development activities for bacterial and viral vaccine programs. Prior to Sanofi Pasteur, Dr. Puvanesarajah as Senior Director of Process and Analytical Development at Wyeth Vaccines, where he developed and scaled up the conjugation manufacturing process for Prevnar®. For his efforts, Dr. Puvanesarajah was the recipient of several prestigious awards, including the “National Medal of Technology” (2007) and “Heroes of Chemistry” award from the American Chemical Society (2003) recognizing outstanding achievement in the vaccine field. He has led process, analytical development and technology transfer activities of several vaccine candidates, including pneumococcal conjugates, protein subunits and influenza viral antigens, from early development through various phases of clinical studies. Dr. Puvanesarajah received his PhD in Polysaccharide Chemistry from York University, Canada.

Robert Corder, PhD — Process and Analytical Development

Dr. Corder brings over 30 years of vaccine experience to Affinivax, with specific expertise in the development of new vaccine processes, designing scale up, and developing cGMP manufacture practices for the production clinical trial materials and commercial vaccines. Most recently, Dr. Corder worked at Lederle/Wyeth/Pfizer Vaccines for 23 years and developed the manufacturing processes for four licensed products including pnuemococcal (Prevnar®) and meningococcal conjugate vaccines. He is experienced in technology transfer from lab scale to full scale manufacturing, leading development of fermentation and recovery processes from bench scale to full-scale production for Prevnar®, Streptococcus pneumoniae conjugate vaccine, Neisseria meningitidis serogroup C conjugate vaccine, and Meningitec vaccine. In addition, Dr. Corder developed fermentation and recovery processes for Corynebacterium diphtheriae, Salmonella typhi, Staphylococcus aureus and Bordetella pertussis. Dr. Corder received his PhD in microbiology from Ohio State University.

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